Amitriptyline is a type of medicine called a tricyclic antidepressant (TCA). When depression occurs, there may be a decreased amount of the chemicals noradrenaline and serotonin released from nerve cells in the brain. When these chemicals are released from nerve cells they act to lighten mood. When they are reabsorbed into the nerve cells, they no longer have an effect on mood.
Amitriptyline works by preventing this re-absorption of noradrenaline and serotonin back into the nerve cells. Therefore, it helps prolong the mood-lightening effect of any released noradrenaline and serotonin. This helps relieve depression. The full benefits of treatment with amitriptyline may not occur for two to four weeks.
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Amitriptyline also blocks receptors in other areas of the body resulting in side effects such as urinary retention. Therefore, amitriptyline may also be used in the treatment of bed-wetting (nocturnal enuresis). When used for this purpose, amitriptyline should generally only be used for a maximum of three months.
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